Pollard Andrew E
Department of Biomedical Engineering, Cardiac Rhythm Management Laboratory, University of Alabama at Birmingham, AL 35294-9440, USA.
J Electrocardiol. 2003;36 Suppl:43-9. doi: 10.1016/j.jelectrocard.2003.09.014.
Membrane equations that describe sarcolemmal currents and ion transfer processes are important building blocks for theoretical studies of action potential propagation in cardiac tissue. Introduction of such ionic models into cellular and tissue networks allows analyses of passive contributions associated with tissue structure to be considered alongside active contributions from myocytes themselves in studies involving arrhythmia initiation, maintenance and termination. Maturation of contemporary membrane equations that attempt to replicate voltage clamp experiments from different species and tissue types with specific examples of modifications to extend those equations for simulations under conditions of rapid pacing, myocardial ischemia and remodeling following myocardial infarction are considered. Additionally, the integrating of membrane equations into models where coupling to represent current flow paths associated with the anisotropic tissue structure is described.
描述肌膜电流和离子转运过程的膜方程是心脏组织中动作电位传播理论研究的重要组成部分。将此类离子模型引入细胞和组织网络，使得在涉及心律失常的起始、维持和终止的研究中，能够在考虑心肌细胞自身的主动作用的同时，一并考虑与组织结构相关的被动作用。本文探讨了当代膜方程的发展，这些方程试图通过特定的修改示例来复制不同物种和组织类型的电压钳实验，以扩展这些方程，用于快速起搏、心肌缺血和心肌梗死后重塑条件下的模拟。此外，还介绍了将膜方程整合到模型中的情况，在这些模型中描述了与各向异性组织结构相关的电流流动路径的耦合。
