Liu J F, Wang Q Z, Hou J
Department of Thoracic Surgery, Fourth Hospital, Hebei Medical University, 12 Jiankang Road, Shijiazhuang 050011, China.
Br J Surg. 2004 Jan;91(1):90-8. doi: 10.1002/bjs.4402.
Southern Hebei Province has one of the highest incidences of oesophageal cancer in the world. This study describes a single-centre experience with oesophagectomy for this condition.
The reported articles on surgical treatment for cancer of the oesophagus and gastric cardia from a single department between September 1952 and December 2000 were summarized and the results compared.
Between September 1952 and December 2000, the resectability rate increased from 78.8 to 96.0 per cent for oesophageal cancer and from 69.6 to 94.8 per cent for cancer of the cardia. The surgical mortality rate decreased from 4.6 to 1.1 per cent. There was little change in the overall 5-year survival rate; it increased from 21.2 to 23.9 per cent for patients with oesophageal cancer and from 15.2 to 17.6 per cent for those with cancer of the cardia.
The rate of postoperative complications and deaths following oesophagectomy for cancer has fallen steadily over the past five decades but long-term survival remains disappointing. Improved survival is likely to be dependent on earlier diagnosis and adjunctive therapies.
河北省南部是世界上食管癌发病率最高的地区之一。本研究描述了针对这种疾病进行食管切除术的单中心经验。
总结了1952年9月至2000年12月间来自同一科室关于食管癌和贲门癌手术治疗的报道文章，并比较结果。
1952年9月至2000年12月间，食管癌的可切除率从78.8%提高到96.0%，贲门癌的可切除率从69.6%提高到94.8%。手术死亡率从4.6%降至1.1%。总体5年生存率变化不大；食管癌患者从21.2%提高到23.9%，贲门癌患者从15.2%提高到17.6%。
在过去五十年中，癌症食管切除术后的并发症和死亡率稳步下降，但长期生存率仍然令人失望。生存率的提高可能依赖于早期诊断和辅助治疗。
