Pelkonen Paula M, Tarvainen Kyllikki, Hynninen Arja, Kallio Eva R K, Henttonen Keikki, Palva Airi, Vaheri Antti, Vapalahti Olli
Faculty of Veterinary Medicine, Helsinki, Finland.
Emerg Infect Dis. 2003 Nov;9(11):1458-61. doi: 10.3201/eid0911.020814.
Cowpox with a severe, generalized eruption was diagnosed in an atopic 4-year-old girl by electron microscopy, virus isolation, polymerase chain reaction, and immunoglobulin (Ig) M and low-avidity IgG antibodies. The hemagglutinin gene of the isolate clustered with a Russian cowpox virus strain, and more distantly, with other cowpox and vaccinia virus strains. The patient's dog had orthopoxvirus-specific antibodies, indicating a possible transmission route. In Finnish wild rodents, orthopoxvirus seroprevalences were 0%-92%, in humans the seroprevalence was 100% in the age group >50, decreasing towards younger age groups.
通过电子显微镜检查、病毒分离、聚合酶链反应以及免疫球蛋白（Ig）M和低亲和力IgG抗体检测，确诊一名患有严重全身性皮疹的特应性4岁女童感染了牛痘病毒。分离出的病毒血凝素基因与一株俄罗斯牛痘病毒毒株聚类，且与其他牛痘病毒和痘苗病毒毒株的亲缘关系更远。该患者的狗具有正痘病毒特异性抗体，提示了一种可能的传播途径。在芬兰野生啮齿动物中，正痘病毒血清阳性率为0%至92%，在人类中，50岁以上年龄组的血清阳性率为100%，且随着年龄组变年轻而降低。
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