Ruiz de Oña Lacasta J M, García de Pedro J, Puente Maestu L, Llorente Iñigo D, Celdrán Gil J, Cubillo Marcos J M
Unidad de Gestión Clínica de Neumología, Hospital Nuestra Señora del Prado, Talavera de la Reina, Toledo, Spain.
Arch Bronconeumol. 2004 Jan;40(1):20-3.
During physical exertion, the ventilatory response of patients with severe chronic obstructive pulmonary disease (COPD) is more rapid and shallow than that of healthy subjects. There is evidence that exercise training can alter breathing pattern in COPD patients. The purpose of the present study was to observe the effects of physical training on patients with severe COPD and to determine whether or not any possible changes were maintained over time.
Patients with severe COPD without bronchial reversibility were enrolled in a randomized controlled trial of a peripheral muscle training program carried out in a hospital setting. All enrolled patients were clinically stable, without exacerbation, and were randomly assigned to a training program of high (group A) or low (group B) intensity.
Thirty-five men with severe COPD in stable condition (mean [SD] forced expiratory volume in 1 second at 41%[7%]) were enrolled in the study. The mean age was 64(5) years. Group A underwent training at 70(22) W and group B at 35(10) W, such that the estimated total work was 8050(2882) kJ in group A and 4044(1205) kJ in group B. Breathing pattern changes were detected in exercise tests only for group A patients, but the changes were not maintained 12 months after the end of the program.
Intense training produces changes in the breathing pattern of patients with severe COPD. The changes are not specific to the task performed, not dependent on lactate production, and not maintained over the long term.
在体力活动期间，重度慢性阻塞性肺疾病（COPD）患者的通气反应比健康受试者更快且更浅。有证据表明运动训练可改变COPD患者的呼吸模式。本研究的目的是观察体育锻炼对重度COPD患者的影响，并确定任何可能的变化是否随时间持续存在。
无支气管可逆性的重度COPD患者参加了在医院环境中进行的外周肌肉训练计划的随机对照试验。所有入选患者临床稳定，无病情加重，并被随机分配至高（A组）或低（B组）强度训练计划。
35名病情稳定的重度COPD男性患者（一秒用力呼气量平均[标准差]为41%[7%]）纳入研究。平均年龄为64（5）岁。A组以70（22）W进行训练，B组以35（10）W进行训练，因此A组估计总功为8050（2882）kJ，B组为4044（1205）kJ。仅在A组患者的运动测试中检测到呼吸模式变化，但在训练计划结束12个月后这些变化未持续存在。
高强度训练会使重度COPD患者的呼吸模式发生变化。这些变化并非特定于所执行的任务，不依赖于乳酸生成，且不会长期持续。
