Lee S H, Bae H J, Kwon S J, Kim H, Kim Y H, Yoon B W, Roh J K
Department of Neurology, Seoul National University, and Neuroscience Research Institute, SNUMRC, Korea.
Neurology. 2004 Jan 13;62(1):72-6. doi: 10.1212/01.wnl.0000101463.50798.0d.
Cerebral microbleeds (CMB) may be indicative of a hemorrhage-prone microangiopathy.
To determine if increased numbers of these lesions are predictive of intracerebral hemorrhage (ICH), especially in terms of a distributional association.
The authors examined consecutively 227 patients with acute stroke. CMB were counted using T2*-weighted gradient echo MRI data, and old lacunes and leukoaraiosis were also evaluated. The associations between the vascular risk factors and ICH were analyzed. With use of multivariate logistic regression analysis, the locations of the CMB or the old lacunes, which were categorized as being in the corticosubcortical area, the deep gray matter area, or the infratentorial area, were examined with regard to their relationships to the locations of the ICH.
The degrees of the CMB (r = 0.43, p < 0.01) and leukoaraiosis (r = 0.20, p < 0.01) were well correlated with the presence of ICH. Multivariate analysis revealed that the grades of the CMB were associated with the presence of ICH (p < 0.01, odds ratio [OR] = 2.67). CMB in the corticosubcortical area (p < 0.01, OR = 5.50) or deep gray matter (p < 0.01, OR = 2.55) were strongly associated with the presence of ICH in the same area, but no such association was observed in the case of CMB in the infratentorial area or in the case of old lacunes in any area.
Cerebral microbleeds are strongly associated with the presence of intracerebral hemorrhage, and the distributional associations are also quite strong.
脑微出血（CMB）可能提示存在易于出血的微血管病变。
确定这些病灶数量的增加是否可预测脑出血（ICH），尤其是在分布关联方面。
作者连续检查了227例急性卒中患者。使用T2 *加权梯度回波MRI数据对脑微出血进行计数，并对陈旧性腔隙和脑白质疏松症进行评估。分析血管危险因素与脑出血之间的关联。使用多因素逻辑回归分析，检查脑微出血或陈旧性腔隙的位置（分为皮质下皮质区域、深部灰质区域或幕下区域）与脑出血位置之间的关系。
脑微出血程度（r = 0.43，p < 0.01）和脑白质疏松症程度（r = 0.20，p < 0.01）与脑出血的存在密切相关。多因素分析显示，脑微出血分级与脑出血的存在相关（p < 0.01，比值比[OR] = 2.67）。皮质下皮质区域的脑微出血（p < 0.01，OR = 5.50）或深部灰质的脑微出血（p < 0.01，OR = 2.55）与同一区域脑出血的存在密切相关，但幕下区域的脑微出血或任何区域的陈旧性腔隙均未观察到这种关联。
脑微出血与脑出血的存在密切相关，且分布关联也很强。
