Lombardi T, Samson J, Plantier F, Husson C, Küffer R
Laboratory of Histopathology, Division of Stomatology, Faculty of Medicine, University of Geneva, Switzerland.
J Oral Pathol Med. 2004 Feb;33(2):115-20. doi: 10.1111/j.1600-0714.2004.00194.x.
Purposely, cosmetic injections in orofacial tissues of various resorbable, biodegradable, or permanent fillers may be followed by development of foreign-body granulomas. The aim of this article is to contribute to the histologic identification of the filler material.
Histologic and clinical features of 11 cases of granulomas on orofacial fillers are described.
Only 3/11 patients knew the nature of the injected product. Four histologic patterns were found: (i) Artecoll, (ii) Dermalive, and (iii) New-Fill granuloma, all three of the classic giant cell granuloma type, differing in respect of foreign particles; and (iv) Liquid Silicone granuloma, which featured a cystic and macrophagic type. Information was often missing or misleading, patients or practitioners being reluctant to give the details.
Increasing demand for orofacial tissue augmentation makes pathologists face new, and sometimes, puzzling granuloma types. Identification of the foreign product might be required for therapeutic or medico-legal reasons.
在口面部组织中故意注射各种可吸收、可生物降解或永久性填充剂进行美容时，可能会继发异物肉芽肿。本文旨在助力填充材料的组织学鉴定。
描述了11例口面部填充剂所致肉芽肿的组织学和临床特征。
11例患者中只有3例知道所注射产品的性质。发现了四种组织学类型：（i）爱贝芙，（ii）德美莱，以及（iii）纽弗隆肉芽肿，这三种均为经典的巨细胞肉芽肿类型，在异物颗粒方面存在差异；（iv）液体硅胶肉芽肿，其特征为囊性和巨噬细胞型。信息常常缺失或具有误导性，患者或从业者不愿提供细节。
对面部组织填充的需求不断增加，使得病理学家面临新的、有时令人困惑的肉芽肿类型。出于治疗或法医学原因，可能需要鉴定异物产品。
