Baz T I
Rinderpest-like Diseases and Bluetongue Laboratory, Veterinary Serum and Vaccine Research Institute, Abbasia, Cairo, Egypt.
Rev Sci Tech. 1992 Sep;11(3):867-72. doi: 10.20506/rst.11.3.628.
In Egypt, bovine virus diarrhoea-mucosal disease (BVD-MD) was initially detected as the result of a serological survey of cattle and sheep, using the serum neutralisation test. In 1970, the causal pestivirus was isolated from bovine calves and buffalo calves with pneumonia and enteritis. Mixed viral infections were also prevalent. Cases of immune tolerance were identified. The Egyptian industry had complained of unthrifty cattle and high death rates of bovine calves and buffalo calves. A rinderpest outbreak in 1982 involved some cattle and buffalo which had been vaccinated against the disease, and such animals were positive to the gel diffusion test for BVD-MD pestivirus. Extensive immunosuppression due to BVD MD virus was suspected, because the attenuated cell-culture vaccine against rinderpest, issued in Egypt since 1965, had not been tested for freedom from non-cytopathic BVD-MD virus. Experimental infection of susceptible sheep with BVD-MD virus resulted in symptoms of Border disease. Innocuity of the attenuated C24V bovine pestivirus vaccine for animal tissues and the immune system of calves was confirmed.
在埃及，牛病毒性腹泻-黏膜病（BVD-MD）最初是通过血清中和试验对牛和羊进行血清学调查时被检测到的。1970年，从患有肺炎和肠炎的牛犊和水牛犊中分离出了致病性瘟病毒。混合病毒感染也很普遍。还发现了免疫耐受病例。埃及的畜牧业曾抱怨牛生长不良以及牛犊和水牛犊死亡率高。1982年的一场牛瘟疫情涉及一些已接种该病疫苗的牛和水牛，这些动物对BVD-MD瘟病毒的凝胶扩散试验呈阳性。由于怀疑自1965年起在埃及发放的抗牛瘟减毒细胞培养疫苗未经过无非细胞病变性BVD-MD病毒的检测，所以怀疑BVD-MD病毒导致了广泛的免疫抑制。用BVD-MD病毒对易感绵羊进行实验性感染后出现了边界病症状。已证实减毒的C24V牛瘟病毒疫苗对动物组织和牛犊的免疫系统无害。
