更年期对血清高密度脂蛋白胆固醇水平的影响。
Effect of menopause on serum HDL-cholesterol level.
作者信息
Sultan Norin, Nawaz Muhammad, Sultan Ambreen, Fayaz Muhammad, Baseer Abdul
机构信息
Department of Biochemistry, Ayub Medical College, Abbottabad.
出版信息
J Ayub Med Coll Abbottabad. 2003 Jul-Sep;15(3):24-6.
BACKGROUND
There is a marked difference in the risk of coronary heart disease between men and women of reproductive age but this gap closes with advancing age. It seems likely that some factors of reproductive physiology are responsible for this. The present study was designed to evaluate the difference in HDL Cholesterol level in premenopausal and postmenopausal women in relation with change of estradiol level.
METHODS
Fifty premenopausal and 50 postmenopausal women were included in the study. Estradiol was estimated by radioimmuoassay while HDL-C was estimated by Kit method.
RESULTS
There was a significant (p < 0.01) decrease in the HDL-C level of the postmenopausal women (46.72 +/- 1.009) as compared with premenopausal women (63.68 +/- 1.78).
CONCLUSION
HDL-C is an independent risk factor for coronary heart disease. This study favours the view that decrease in estradiol level and associated decrease in HDL-C seen in postmenopausal women may be responsible for the increased risk of coronary heart disease after menopause.
背景
育龄期男性和女性患冠心病的风险存在显著差异，但随着年龄增长这种差距会缩小。生殖生理学的某些因素似乎对此负有责任。本研究旨在评估绝经前和绝经后女性高密度脂蛋白胆固醇水平的差异与雌二醇水平变化的关系。
方法
本研究纳入了50名绝经前女性和50名绝经后女性。通过放射免疫分析法测定雌二醇，采用试剂盒法测定高密度脂蛋白胆固醇（HDL-C）。
结果
与绝经前女性（63.68±1.78）相比，绝经后女性的HDL-C水平显著降低（46.72±1.009，p<0.01）。
结论
HDL-C是冠心病的独立危险因素。本研究支持这样的观点，即绝经后女性雌二醇水平降低以及随之而来的HDL-C水平降低可能是绝经后冠心病风险增加的原因。
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