Seto Elaine S, Bellen Hugo J
Program in Developmental Biology, Department of Molecular and Human Genetics, Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Trends Cell Biol. 2004 Jan;14(1):45-53. doi: 10.1016/j.tcb.2003.11.004.
Signaling through the highly conserved Wingless/Wnt pathway plays a crucial role in a diverse array of developmental processes, many of which depend upon the precise regulation of Wingless/Wnt signaling levels. Recent evidence has indicated that the intracellular trafficking of Wingless/Wnt signaling components can result in significant changes in the level of signaling. Here, we examine three mechanisms through which intracellular trafficking might regulate Wingless signaling--the degradation of Wingless, its transport and the transduction of its signal. The intracellular trafficking of several Wingless/Wnt signaling components, including LRP5, LRP6, Dishevelled and Axin, as well as the functional implications of protein localization on Wingless/Wnt signaling, will be discussed.
通过高度保守的无翅型/翼状螺旋转录因子（Wingless/Wnt）信号通路进行的信号传导，在各种各样的发育过程中起着至关重要的作用，其中许多过程都依赖于对无翅型/翼状螺旋转录因子信号水平的精确调控。最近的证据表明，无翅型/翼状螺旋转录因子信号成分的细胞内运输可导致信号水平发生显著变化。在此，我们研究细胞内运输可能调控无翅型信号的三种机制——无翅型的降解、其运输及其信号转导。我们还将讨论几种无翅型/翼状螺旋转录因子信号成分的细胞内运输，包括低密度脂蛋白受体相关蛋白5（LRP5）、低密度脂蛋白受体相关蛋白6（LRP6）、散乱蛋白（Dishevelled）和轴抑制蛋白（Axin），以及蛋白质定位对无翅型/翼状螺旋转录因子信号传导的功能影响。
