Murphy Christopher F, Alexopoulos George S
Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA.
Am J Geriatr Psychiatry. 2004 Jan-Feb;12(1):50-6.
Many older adults with major depression (MDD) present with impairment in initiation and perseveration (IP) tests. However, it remains unclear how these abnormalities change during the course of depression.
The authors studied the longitudinal covariation of depression severity and IP functioning in 157 depressed older adults with MDD. Patients with and without baseline IP impairment were studied on three occasions over 1 year.
Depression severity was associated with concurrent IP scores; however, despite IP improvement, those with impaired baseline IP functioning did not reach the level of their non-impaired counterparts.
The persistence of IP abnormalities suggests that these patients require careful treatment planning and follow-up, given that earlier studies noted an association of abnormal IP with disability and poor outcomes of depression treatment.
许多患有重度抑郁症（MDD）的老年人在启动和持续操作（IP）测试中表现出功能受损。然而，目前尚不清楚这些异常在抑郁症病程中如何变化。
作者研究了157名患有MDD的抑郁症老年人中抑郁严重程度与IP功能的纵向协变关系。对有和没有基线IP功能受损的患者在1年的时间里进行了3次研究。
抑郁严重程度与同时期的IP分数相关；然而，尽管IP功能有所改善，但基线IP功能受损的患者并未达到未受损患者的水平。
IP异常的持续存在表明，鉴于早期研究指出IP异常与残疾及抑郁症治疗不良结果相关，这些患者需要仔细的治疗规划和随访。
