López-Abente G, Pollán M, Monge V, Martínez-Vidal A
Cancer Epidemiology Unit, Carlos III Institute of Health, Madrid, Spain.
Cancer Detect Prev. 1992;16(5-6):265-71.
The associations between cigarette smoking and alcohol consumption and laryngeal cancer were examined in a case-control study carried out between 1982 and 1985 in Madrid. The analysis was based on 50 histologically confirmed male cases and 103 age- and sex-matched controls (45 hospitalized and 58 from the general population). A dose-response effect was observed for cigarette smoking, with an odds ratio (OR) of 4.33 (95% confidence interval of 1.22 to 15.41) for smokers of 30 or more cigarettes per day, when compared with those smoking less than 10 cigarettes per day. The risk clearly rose in line with the length of the smoking habit. In addition, for smokers of black tobacco, the risk was more than double that for smokers of blond tobacco, irrespective of the depth of inhalation. ORs for alcohol consumption rose significantly in accordance with the average grams intake per week and the overall lifetime consumption, but not with years of drinking. The time trends of risks for duration of alcohol consumption suggest the existence of phenomena related to individual susceptibility. A dose response effect was observed in supraglottal and glottal tumors. The effect of the joint exposure to both tobacco and alcohol fit to a multiplicative model.
1982年至1985年期间在马德里开展了一项病例对照研究，对吸烟、饮酒与喉癌之间的关联进行了调查。分析基于50例经组织学确诊的男性病例以及103名年龄和性别匹配的对照（45名住院患者和58名普通人群）。观察到吸烟存在剂量反应效应，每天吸烟30支或更多的吸烟者与每天吸烟少于10支的吸烟者相比，比值比（OR）为4.33（95%置信区间为1.22至15.41）。风险显然随着吸烟习惯的时长而上升。此外，对于吸食黑烟草的吸烟者，无论吸入深度如何，其风险是吸食金色烟草吸烟者的两倍多。饮酒的OR值随着每周平均摄入量和一生总摄入量的增加而显著上升，但与饮酒年限无关。饮酒时长的风险随时间变化趋势表明存在与个体易感性相关的现象。在声门上和声门肿瘤中观察到剂量反应效应。同时接触烟草和酒精的效应符合相乘模型。
