Maier H, Weidauer H
Hals-Nasen-Ohren-Klinik, Universität Heidelberg.
Fortschr Med. 1995 Apr 20;113(11):157-60.
Both chronic alcohol consumption and chronic use of nicotine must be considered major risk factors for carcinogenesis in the oral cavity, pharynx and larynx. In the case of both noxae, increasing consumption correlates with an increase in the cancer risk in the sense of a dose-effect relationship. Smokers of non-filtertip cigarettes have a higher cancer risk than those smoking filtertip cigarettes. The alcohol-associated risk of developing cancer depends decisively on the overall daily consumption, but not on the nature of the alcoholic beverage. With respect to carcinogenesis, alcohol and nicotine consumed together develop a synergistic action and have a multiplicative effect on the cancer risk.
长期饮酒和长期使用尼古丁都必须被视为口腔、咽和喉癌发生的主要危险因素。就这两种有害物质而言,摄入量增加与癌症风险增加存在剂量效应关系。吸非过滤嘴香烟的人比吸过滤嘴香烟的人患癌风险更高。与酒精相关的患癌风险主要取决于每日总摄入量,而不取决于酒精饮料的种类。在致癌方面,同时摄入酒精和尼古丁会产生协同作用,对癌症风险有倍增效应。