Kuhn F E, Mohler E R, Rackley C E
Georgetown University Medical Center, Washington, D.C. 20007.
Clin Cardiol. 1992 Dec;15(12):883-90. doi: 10.1002/clc.4960151207.
Although much emphasis has been placed on the role of cholesterol and lipoproteins in atherosclerotic plaque formation, recent studies suggest that lipids have other vascular actions which may contribute to the pathogenesis of myocardial ischemia. These include deleterious effects of lipids on platelet and endothelial cell function, coagulation, fibrinolysis, and prostacyclin metabolism. The purpose of this report is to review recent data regarding the nonatherogenic effects of lipids and provide insight as to how lipid lowering might contribute to clinically important improvements in vascular biology.
尽管人们一直非常强调胆固醇和脂蛋白在动脉粥样硬化斑块形成中的作用，但最近的研究表明，脂质具有其他血管作用，可能会导致心肌缺血的发病机制。这些作用包括脂质对血小板和内皮细胞功能、凝血、纤维蛋白溶解和前列环素代谢的有害影响。本报告的目的是回顾有关脂质非致动脉粥样硬化作用的最新数据，并深入探讨降脂如何有助于在血管生物学方面取得具有临床重要意义的改善。
