Penttinen J
Kuopio Regional Institute of Occupational Health, Finland.
Am J Epidemiol. 1995 Apr 15;141(8):716-8. doi: 10.1093/oxfordjournals.aje.a117492.
An excess mortality for violence (suicides and injuries) has been observed following the use of cholesterol-lowering drugs. It has been suggested that low cholesterol is associated with depression by modifying the serotonin metabolism. In this paper, a new hypothesis concerning the association among serum lipids, depression, and atherosclerosis is proposed. The hypothesis is based on epidemiologic evidence concerning serum lipids, depression, violent deaths, and atherosclerosis. It is also based on previous results concerning a cytokine, interleukin-2. Recent observations indicate that interleukin-2 has an important role in lipid metabolism, depression, and atherosclerosis.
在使用降胆固醇药物后，观察到暴力行为（自杀和伤害）导致的超额死亡率。有人提出，低胆固醇通过改变血清素代谢与抑郁症有关。本文提出了一个关于血脂、抑郁症和动脉粥样硬化之间关联的新假说。该假说基于有关血脂、抑郁症、暴力死亡和动脉粥样硬化的流行病学证据。它还基于先前关于一种细胞因子——白细胞介素-2的研究结果。最近的观察表明，白细胞介素-2在脂质代谢、抑郁症和动脉粥样硬化中起重要作用。
