Osterland C K, St Louis E A
McGill University School of Medicine, Thorp Laboratories of Clinical Immunology, Royal Victoria Hospital, Montreal, Que., Canada.
Gerontology. 1992;38(6):301-7. doi: 10.1159/000213346.
The level of activity in the autologous mixed lymphocyte reaction (AMLR) was studied in populations of young and old subjects. AMLR activity was reduced in the older age group. A subpopulation of the older age group who had Alzheimer's disease was shown to have the lowest AMLR values. Within this group, those with a history indicating a more rapid development of CNS-related disability from senescence showed the weakest AMLR responses. The AMLR values correlated neither with sex, nutritional status nor history of infections. This impairment of a central regulating immune reaction may be a significant variable in manifestations of the aging process.
对年轻和老年人群体的自体混合淋巴细胞反应（AMLR）活性水平进行了研究。老年组的AMLR活性降低。患有阿尔茨海默病的老年亚组显示出最低的AMLR值。在该组中，有从衰老开始中枢神经系统相关残疾发展更快病史的人表现出最弱的AMLR反应。AMLR值与性别、营养状况或感染史均无关联。这种中枢调节免疫反应的损害可能是衰老过程表现中的一个重要变量。
