Bjørke Monsen Anne-Lise, Vollset Stein Emil, Refsum Helga, Markestad Trond, Ueland Per Magne
Department of Pediatrics, University of Bergen, Bergen, Norway.
Biol Neonate. 2004;85(4):249-55. doi: 10.1159/000076362. Epub 2004 Jan 21.
Hematological parameters, serum cobalamin and folate levels, and the concentrations of the functional markers plasma methylmalonic acid and total homocysteine were determined in 173 newborns and 46 infants at 6 weeks to see whether maternal smoking influences the hematological parameters and the vitamin status of the newborn. At birth, there was a strong inverse correlation between the number of cigarettes smoked per day during pregnancy and red blood cell count (r = -0.56, p = 0.001) and hemoglobin level (r = -0.52, p = 0.003) in the newborns. Neonates born to smoking mothers had lower red blood cell counts and lower hemoglobin and serum cobalamin levels as compared with infants born to nonsmoking mothers. At 6 weeks, maternal smoking significantly predicted the methylmalonic acid and total homocysteine levels, suggesting an influence from smoking on the cobalamin function in these infants.
对173名新生儿和46名6周龄婴儿测定了血液学参数、血清钴胺素和叶酸水平，以及功能性标志物血浆甲基丙二酸和总同型半胱氨酸的浓度，以观察母亲吸烟是否会影响新生儿的血液学参数和维生素状态。出生时，孕期每日吸烟量与新生儿红细胞计数（r = -0.56，p = 0.001）和血红蛋白水平（r = -0.52，p = 0.003）之间存在很强的负相关。与不吸烟母亲所生婴儿相比，吸烟母亲所生新生儿的红细胞计数、血红蛋白和血清钴胺素水平较低。在6周龄时，母亲吸烟显著预测了甲基丙二酸和总同型半胱氨酸水平，表明吸烟对这些婴儿的钴胺素功能有影响。
