人圆环病毒

Human circoviruses.

作者信息

Biagini Philippe

机构信息

Unité des Virus Emergents, EA 3292, Laboratoire de Virologie Moléculaire, Etablissement Français du Sang Alpes-Méditerranée et Faculté de Médecine, 149, Boulevard Baille, 13005 Marseille, France.

出版信息

Vet Microbiol. 2004 Feb 4;98(2):95-101. doi: 10.1016/j.vetmic.2003.10.004.

DOI:10.1016/j.vetmic.2003.10.004

PMID:14741121

Abstract

TT virus (TTV) and TTV-like mini virus (TLMV) represent the first described human circoviruses. They do not show significant sequence homology with any other animal circovirus identified to date. They are both detected with high prevalences in various body fluids. The spread mode may include the parenteral way, the transmission by saliva droplets and the fecal-oral route. Genetic variability within a viral group is high and the co-infection by distinct viral strains is common in a given individual. The description of several messenger RNAs obtained after multiple splicing revealed a specific transcription profile. Despite apparent asymptomatic infections, the possible association of variants of TTV and TLMV with a given pathology cannot be formally ruled out.

摘要

TT病毒（TTV）和TTV样微小病毒（TLMV）是首次被描述的人类环状病毒。它们与迄今鉴定出的任何其他动物环状病毒均无明显的序列同源性。在各种体液中均能以高流行率检测到它们。传播方式可能包括肠道外途径、唾液飞沫传播和粪-口途径。病毒群体内的基因变异性很高，在同一个体中不同病毒株的共同感染很常见。对多次剪接后获得的几种信使核糖核酸的描述揭示了一种特定的转录谱。尽管明显存在无症状感染，但不能完全排除TTV和TLMV变体与特定病理学之间可能存在的关联。