Harding John C S
Harding Swine Veterinary Service Inc, PO Box 2922, Humboldt, Sask, Canada S0K 2A0.
Vet Microbiol. 2004 Feb 4;98(2):131-5. doi: 10.1016/j.vetmic.2003.10.013.
Since its discovery and characterization in western Canada in 1995, the distribution of post-weaning multisystemic wasting syndrome (PMWS) has grown and the syndrome is undoubtedly recognized worldwide. More recently, there is a heightened interest in several potentially related conditions including porcine dermatitis and nephropathy syndrome (PDNS), proliferative and necrotizing pneumonia (PNP), congenital tremors (CT-AII), perinatal myocarditis and reproductive failure. Although the causality of porcine circovirus type 2 (PCV2) has recently been proven [Vet. Pathol. 37 (2000) 254; J. Comp. Pathol. 122 (2000) 9; J. Vet. Diagn. Invest. 13 (2001) 185], PCV2 is present in both diseased and healthy pig populations. Furthermore, recent serologic studies have shown that there are no significant differences in PCV2 specific IgG titres between PMWS clinical and non-clinical herds (Harding et al., in press). Clearly, the transmission, epidemiology, and factors triggering clinical expression are poorly understood. With these uncertainties in mind, the objective of this paper is to review the clinical expression and emergence of PMWS and the potentially associated disease syndromes including PDNS.
自1995年在加拿大西部发现并鉴定出断奶后多系统消耗综合征（PMWS）以来，该综合征的分布范围不断扩大，现已在全球范围内得到公认。最近，人们对几种可能与之相关的病症兴趣日增，包括猪皮炎和肾病综合征（PDNS）、增生性和坏死性肺炎（PNP）、先天性震颤（CT-AII）、围产期心肌炎和繁殖障碍。尽管最近已证实2型猪圆环病毒（PCV2）具有致病性[《兽医病理学》37卷（2000年）第254页；《比较病理学杂志》122卷（2000年）第9页；《兽医诊断调查杂志》13卷（2001年）第185页]，但在患病猪群和健康猪群中均存在PCV2。此外，最近的血清学研究表明，PMWS临床发病猪群和非临床发病猪群之间的PCV2特异性IgG滴度没有显著差异（哈丁等人，即将发表）。显然，人们对其传播、流行病学以及引发临床症状的因素了解甚少。鉴于这些不确定性，本文旨在综述PMWS的临床症状及出现情况以及包括PDNS在内的可能与之相关的疾病综合征。
