Bouza E, Muñoz P
Servicio de Microbiología Clínica y E. Infecciosas, Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid, Spain.
Clin Microbiol Infect. 2004 Mar;10 Suppl 1:76-85. doi: 10.1111/j.1470-9465.2004.00842.x.
Blastoschizomyces capitatus, Scedosporium prolificans and S. apiospermum are emerging fungal pathogens that may cause disseminated disease in neutropenic patients. They can present as fever resistant to antibiotics and to wide-spectrum antifungal agents, although they may involve almost every organ. The proportion of recovery from blood cultures is high and they are characteristically resistant to most antifungal agents. Prognosis is poor unless patients recover from neutropenia. Voriconazole has good in-vitro activity and is currently the drug of choice for these infections.
头裂芽生菌、多育赛多孢和尖端赛多孢是新出现的真菌病原体，可在中性粒细胞减少的患者中引起播散性疾病。它们可表现为对抗生素和广谱抗真菌药物耐药的发热，尽管它们可能累及几乎每个器官。从血培养中分离出这些病原体的比例很高，并且它们对大多数抗真菌药物具有特征性耐药。除非患者从中性粒细胞减少中恢复，否则预后很差。伏立康唑具有良好的体外活性，是目前治疗这些感染的首选药物。
