Watt Diana J, Jones Gareth E, Goldring Kirstin
Department of Anatomy, Brighton and Sussex Medical School, Medical School Building, Falmer, Brighton, East Sussex BN1 9PX, UK.
Glycoconj J. 2002;19(7-9):615-9. doi: 10.1023/B:GLYC.0000014093.23509.92.
The dogma that a cell is rigidly committed to one tissue type has been heavily challenged over the past few years with numerous reports of transdifferentiation of cells between different lineages. Cells capable of entering lineages other than that of their tissue of origin have been identified in several diverse tissues. Recently we have focussed on a non-committed myogenic cell within the dermis that is capable, under certain conditions, of expressing muscle specific markers and even fusing to the terminally differentiated stage of muscle cell development. We have identified galectin-1 as being a potent factor implicated in this process. In this review we discuss our findings and consider the involvement of galectin-1 in muscle determination, differentiation and regeneration.
在过去几年里，细胞严格地固定于一种组织类型的这一信条受到了极大挑战，有大量关于不同谱系细胞转分化的报道。在多种不同组织中已鉴定出能够进入其起源组织以外谱系的细胞。最近，我们聚焦于真皮内一种未定向的成肌细胞，在某些条件下，这种细胞能够表达肌肉特异性标志物，甚至融合至肌肉细胞发育的终末分化阶段。我们已确定半乳糖凝集素-1是参与这一过程的一个重要因子。在这篇综述中，我们讨论我们的研究发现，并思考半乳糖凝集素-1在肌肉决定、分化和再生中的作用。
