Budson Andrew E, Michalska Kalina J, Sullivan Alison L, Rentz Dorene M, Daffner Kirk R, Schacter Daniel L
Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Cogn Behav Neurol. 2003 Mar;16(1):16-27. doi: 10.1097/00146965-200303000-00003.
To better understand memory distortions and false recognition in patients with Alzheimer disease (AD), using a paradigm of categorized color photographs.
Previous research has found that patients with AD and older adults showed similar levels of uncorrected false recognition of semantic associates and of perceptually related novel objects. In contrast to these results, using a paradigm in which semantically related words were accompanied by black and white line drawings, it was found that patients with AD showed a trend toward higher levels of uncorrected false recognition compared with older adults.
To explore this trend, 24 patients with AD and 24 older adults matched for age, education, and gender were examined using a false recognition paradigm consisting of categorized color photographs (e.g., flowers, motorcycles, cats).
Compared with older adults, patients with AD showed higher levels of uncorrected false recognition, but lower levels of corrected false recognition and lower levels of item-specific recollection.
The authors suggest that these results may be attributable to the poor ability of patients with AD to acquire both gist and item-specific information as well as these patients' inherent frontal lobe dysfunction leading to difficulty inhibiting responses on the basis of familiarity alone.
采用分类彩色照片范式，以更好地理解阿尔茨海默病（AD）患者的记忆扭曲和错误识别。
先前的研究发现，AD患者和老年人在对语义关联以及感知相关新物体的未校正错误识别水平上相似。与这些结果相反，在一个语义相关词伴有黑白线条图的范式中，发现AD患者与老年人相比有更高水平的未校正错误识别趋势。
为探究这一趋势，对24名AD患者和24名年龄、教育程度及性别相匹配的老年人，使用由分类彩色照片（如花朵、摩托车、猫）组成的错误识别范式进行检查。
与老年人相比，AD患者表现出更高水平的未校正错误识别，但校正错误识别水平较低且特定项目回忆水平较低。
作者认为这些结果可能归因于AD患者获取要点和特定项目信息的能力较差，以及这些患者固有的额叶功能障碍导致仅基于熟悉度抑制反应存在困难。
