金黄胺，一种从坦桑尼亚马钱叶子中提取的抗疟无水铵碱。

Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves.

作者信息

Frédérich Michel, Cristino Assunção, Choi Young Hae, Verpoorte Robert, Tits Monique, Angenot Luc, Prost Elise, Nuzillard Jean-Marc, Zèches-Hanrot Monique

机构信息

Division of Pharmacognosy, Section Metabolomics, Institute of Biology, Leiden University, Leiden, The Netherlands.

出版信息

Planta Med. 2004 Jan;70(1):72-6. doi: 10.1055/s-2004-815461.

DOI:10.1055/s-2004-815461

PMID:14765299

Abstract

A new derivative of strychnopentamine was isolated from the leaves of Strychnos usambarensis. This compound, named chrysopentamine, was identified by detailed spectroscopic methods (UV, IR, HR-ESI-MS, 1D and 2D NMR). Chrysopentamine presented an original hydroxy substitution on C-14 and an aromatization of the ring D of strychnopentamine leading to anhydronium base properties and exhibited strong antiplasmodial properties (IC (50) less than 1 microM).

摘要

从坦桑尼亚马钱子的叶子中分离出一种士的宁五胺的新衍生物。这种化合物被命名为金黄五胺，通过详细的光谱方法（紫外、红外、高分辨电喷雾电离质谱、一维和二维核磁共振）进行了鉴定。金黄五胺在C-14位有一个独特的羟基取代，士的宁五胺的D环发生芳构化，导致具有无水铵碱性质，并表现出很强的抗疟原虫特性（半数抑制浓度小于1微摩尔）。