Boje Kathleen M K
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14260, USA.
Front Biosci. 2004 Jan 1;9:763-76. doi: 10.2741/1268.
Nitric oxide (nitrogen monoxide; NO) is a simple molecule with diverse biological functions. NO and related reactive nitrogen oxide species (RNOS) mediate intricate physiological and pathophysiological effects in the central nervous system. Depending on environmental conditions, NO and RNOS can initiate and mediate neuroprotection or neurotoxicity either exclusively or synergistically with other effectors. The focus of this review is limited to the neuroprotectant/neurotoxic role of NO in Acquired Immune Deficiency Syndrome (AIDS) Dementia Complex (aka HIV--Associated Dementia; HAD) Amyotrophic Lateral Sclerosis (aka Lou Gehrig's Disease), Alzheimer's Disease, Huntington's Disease, Multiple Sclerosis and Parkinson's Disease. This review will shed light on the question: "How important is NO in neurodegenerative diseases?"
一氧化氮（又称一氧化氮；NO）是一种具有多种生物学功能的简单分子。NO及相关活性氮氧化物（RNOS）在中枢神经系统中介导复杂的生理和病理生理效应。根据环境条件，NO和RNOS可单独或与其他效应物协同引发和介导神经保护或神经毒性。本综述的重点仅限于NO在获得性免疫缺陷综合征（AIDS）痴呆综合征（又称HIV相关性痴呆；HAD）、肌萎缩侧索硬化症（又称卢伽雷氏病）、阿尔茨海默病、亨廷顿病、多发性硬化症和帕金森病中的神经保护/神经毒性作用。本综述将阐明以下问题：“NO在神经退行性疾病中的重要性如何？”
