Volpato Stefano, Pahor Marco, Ferrucci Luigi, Simonsick Eleanor M, Guralnik Jack M, Kritchevsky Stephen B, Fellin Renato, Harris Tamara B
Department of Clinical and Experimental Medicine, University of Ferrara, Via Savonarola, 9, I-44100 Ferrara, Italy.
Circulation. 2004 Feb 10;109(5):607-12. doi: 10.1161/01.CIR.0000109503.13955.00.
Increased levels of acute-phase reactants predict the onset of poor health outcomes. A U-shaped association has been reported between alcohol intake and health outcomes, which suggests that alcohol intake may modify levels of acute-phase reactants. We investigated the relationship between weekly alcohol intake and interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and plasminogen activator inhibitor-1 (PAI-1).
Data are from year 1 of the Health, Aging, and Body Composition study, a biracial cohort of 3075 well-functioning men and women aged 70 to 79 years, living in Memphis, Tenn, and Pittsburgh, Pa. The analysis included 2574 persons (51.2% women; 40.1% black) with complete data. After adjustment for age, race, smoking status, history of diabetes, history of cardiovascular disease, physical activity, high-density lipoprotein cholesterol, antiinflammatory medications, statins, and total fat mass, alcohol intake showed a J-shaped relationship with mean IL-6 (P for quadratic term <0.001) and CRP (P=0.014) levels. The association was consistent in both men and women. Compared with subjects who consumed 1 to 7 drinks per week, those who never drank had an increased likelihood of having high levels of both IL-6 and CRP, as did those who drank 8 or more drinks per week. We found no relationship between alcohol intake and levels of TNF-alpha and PAI-1 (P=0.137 and 0.08, respectively).
In well-functioning older persons, light alcohol consumption is associated with lower levels of IL-6 and CRP. These results might suggest an additional biological explanation to the epidemiological link between moderate alcohol consumption and cardiovascular events.
急性期反应物水平升高预示着不良健康结局的发生。酒精摄入量与健康结局之间呈U型关联，这表明酒精摄入可能会改变急性期反应物的水平。我们研究了每周酒精摄入量与白细胞介素-6（IL-6）、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）和纤溶酶原激活物抑制剂-1（PAI-1）之间的关系。
数据来自健康、衰老和身体成分研究的第1年，该研究是一个由3075名70至79岁功能良好的男性和女性组成的双种族队列，居住在田纳西州孟菲斯市和宾夕法尼亚州匹兹堡市。分析纳入了2574名（51.2%为女性；40.1%为黑人）有完整数据的人。在对年龄、种族、吸烟状况、糖尿病史、心血管疾病史、身体活动、高密度脂蛋白胆固醇、抗炎药物、他汀类药物和总脂肪量进行调整后，酒精摄入量与平均IL-6（二次项P<0.001）和CRP（P=0.014）水平呈J型关系。这种关联在男性和女性中均一致。与每周饮用1至7杯酒的受试者相比，从不饮酒者以及每周饮用8杯或更多酒的受试者，IL-6和CRP水平升高的可能性更大。我们发现酒精摄入量与TNF-α和PAI-1水平之间无关联（分别为P=0.137和0.08）。
在功能良好的老年人中，轻度饮酒与较低的IL-6和CRP水平相关。这些结果可能为适度饮酒与心血管事件之间的流行病学联系提供额外的生物学解释。
