Pagsberg K, Pedersen G, Hansen F M
Ugeskr Laeger. 1989 Aug 21;151(34):2141-4.
A review is presented of antiglomerular basal membrane antibody-mediated glomerulonephritis (anti-GBM-Ab-nephritis) which constitutes 2-5% of all cases of acute glomerulonephritis. The disease frequently commences in the age group 20-30 years but may be encountered in all age groups, in women particularly at 60 years of age. The disease is due to autoantibodies (IgG) to the basal membranes in the glomeruli and alveoli. Deposition of IgG with C3 precipitates an inflammatory reaction which causes renal and possibly also pulmonary damage. It is possible to demonstrate anti-GMB-antibodies in the blood and, by means of immunofluorescence microscopy, these and C3 may be demonstrated in the basal membranes in the glomeruli and alveoli. The disease is still serious but introduction of immune-suppressive treatment and plasmapheresis has improved the prognosis considerably.
本文综述了抗肾小球基底膜抗体介导的肾小球肾炎（抗GBM抗体肾炎），其占急性肾小球肾炎所有病例的2% - 5%。该疾病常始于20 - 30岁年龄组，但各年龄组均可发生，女性尤其在60岁时易患。该病是由针对肾小球和肺泡基底膜的自身抗体（IgG）引起的。IgG与C3的沉积引发炎症反应，导致肾脏甚至可能肺部受损。可在血液中检测到抗GBM抗体，通过免疫荧光显微镜检查，可在肾小球和肺泡的基底膜中检测到这些抗体及C3。该疾病仍然严重，但免疫抑制治疗和血浆置换的引入已显著改善了预后。
