Agarwal S K, Deb M, Prakash K, Sharma A K
Department of Microbiology, Lady Hardinge Medical College, Dr Ram Manohar Lohia Hospital, New Delhi.
Indian J Med Res. 1992 Sep;95:227-9.
Auxotypes and penicillin sensitivity of 102 strains of N. gonorrhoeae were studied. Ten distinct auxotypes on the basis of growth requirement to seven amino acids were observed. The commonest pattern seen was zero auxotype (33.3%), followed by auxotype requiring proline (18.6%). MIC of 72 (71.5%) strains ranged from < 0.003 IU/ml to 0.062 IU/ml of benzyl penicillin. MIC of the other 30 (29.5%) strains was found to be > or = 0.125 IU/ml, indicating penicillin resistance. None of the strains were penicillinase producers. A case of reinfection was also detected on the basis of change in auxotype pattern.
对102株淋病奈瑟菌的菌型及青霉素敏感性进行了研究。根据对七种氨基酸的生长需求观察到十种不同的菌型。最常见的模式是零菌型（33.3%），其次是需要脯氨酸的菌型（18.6%）。72株（71.5%）菌株对苄青霉素的最低抑菌浓度范围为<0.003 IU/ml至0.062 IU/ml。发现其他30株（29.5%）菌株的最低抑菌浓度≥0.125 IU/ml，表明对青霉素耐药。所有菌株均不产青霉素酶。还根据菌型模式的变化检测到一例再感染病例。
