Arini A, Peduzzi R, Piffaretti J C
Schweiz Med Wochenschr. 1983 Apr 2;113(13):462-70.
In a study to determine the epidemiological situation of N. gonorrhoeae (NG) in Switzerland, 149 strains isolated from different regions over the period September 1981 to February 1982 were analyzed for sensitivity to various antibiotics (minimum inhibitory concentration [MIC] for penicillin G, ampicillin, cefuroxime, tetracycline, thiamphenicol, and spectinomycin) and for their auxotype. From the results obtained it can be concluded that (1) the PPNG (penicillinase producing NG) strains are not a problem at present in Switzerland; (2) 15% of the non-penicillinase producing NG strains are "less sensitive" to penicillin G (MIC equal to or greater than 0.5 micrograms/ml); (3) sensitivity level of the NG strains to the various antibiotics assayed and the auxotypes do not show any significant peculiarity when compared to the data reported in other countries; (4) penicillin G should still be used as the first choice antibiotic at present in Switzerland, with spectinomycin, thiamphenicol and cefuroxime as second choice antibiotics; (5) when compared according to the geographical origin of their isolation, the NG strains show specific peculiarities, a fact which could lead to an antibiotic therapy policy more suited to specific regions.
在一项旨在确定瑞士淋病奈瑟菌（NG）流行病学情况的研究中，对1981年9月至1982年2月期间从不同地区分离出的149株菌株进行了分析，以检测其对各种抗生素的敏感性（青霉素G、氨苄西林、头孢呋辛、四环素、甲砜霉素和壮观霉素的最低抑菌浓度[MIC]）及其营养型。从所得结果可以得出以下结论：（1）目前产青霉素酶淋病奈瑟菌（PPNG）菌株在瑞士不是问题；（2）15%的非产青霉素酶淋病奈瑟菌菌株对青霉素G“敏感性较低”（MIC等于或大于0.5微克/毫升）；（3）与其他国家报告的数据相比，淋病奈瑟菌菌株对所检测的各种抗生素的敏感性水平和营养型未显示出任何显著特性；（4）目前在瑞士，青霉素G仍应作为首选抗生素，壮观霉素、甲砜霉素和头孢呋辛作为次选抗生素；（5）根据分离菌株的地理来源进行比较时，淋病奈瑟菌菌株显示出特定特性，这一事实可能导致更适合特定地区的抗生素治疗策略。
