Chiò A, Magnani C, Oddenino E, Tolardo G, Schiffer D
II Department of Neurology, University of Turin, Ospedale Molinette, Torino, Italy.
J Epidemiol Community Health. 1992 Oct;46(5):517-8. doi: 10.1136/jech.46.5.517.
The aim was to determine the reliability of official mortality statistics in estimating long term trends of amyotrophic lateral sclerosis (ALS) in Italy.
The study was a mortality follow up of cases of ALS.
Piedmond Region, northern Italy.
Cases of ALS were identified from multiple sources between 1966 and 1985.
Cause of death was determined for the cases who died between 1970 and 1985. Death certificates were obtained in 488 out of 510 cases (95.7%). ALS was mentioned in 365 (74.8%) of cases. The most frequent erroneous diagnoses were multiple sclerosis and malignant tumours. Demographic variables, such as sex, age at death, province of death, and calendar year of death, did not influence the percentage of true positive cases significantly.
The death certificate diagnosis of ALS appears to be adequate for use in descriptive and analytical epidemiology.
本研究旨在确定官方死亡率统计数据在评估意大利肌萎缩侧索硬化症(ALS)长期趋势方面的可靠性。
本研究为ALS病例的死亡率随访研究。
意大利北部皮埃蒙特大区。
1966年至1985年间通过多种来源确定的ALS病例。
确定了1970年至1985年间死亡病例的死因。510例病例中有488例(95.7%)获得了死亡证明。其中365例(74.8%)病例的死亡证明中提及了ALS。最常见的错误诊断为多发性硬化症和恶性肿瘤。人口统计学变量,如性别、死亡年龄、死亡省份和死亡年份,对真阳性病例的百分比没有显著影响。
ALS的死亡证明诊断似乎足以用于描述性和分析性流行病学研究。