Lilienfeld D E, Chan E, Ehland J, Godbold J, Landrigan P J, Marsh G, Perl D P
Department of Community Medicine, Mount Sinai School of Medicine, New York.
Lancet. 1989 Apr 1;1(8640):710-3. doi: 10.1016/s0140-6736(89)92218-6.
From 1962 to 1984, age-specific mortality for motoneuron disease (MND) in the United States rose in all demographic groups over the age of 40. The increase was seen in both men and women, and both whites and non-whites, and was most pronounced in the elderly (eg, 378% in white women aged 80-84 years). Men were at 50% higher risk than women, and whites had twice the risk of non-whites. These increases may reflect an improvement in case ascertainment, but they also seem to show a true rise in the incidence of MND, particularly among the elderly. Such an increase suggests an environmental aetiology.
1962年至1984年期间，美国40岁以上各年龄组的运动神经元病（MND）特异性死亡率均有所上升。男性和女性、白人和非白人都出现了这种增长，且在老年人中最为明显（例如，80 - 84岁白人女性中增长了378%）。男性患病风险比女性高50%，白人患病风险是非白人的两倍。这些增长可能反映了病例确诊率的提高，但似乎也表明MND的发病率确实上升了，尤其是在老年人中。这种增长提示存在环境病因。
