螯合剂的致糖尿病作用和嗜酸性作用。
The diabetogenic and acidotropic effects of chelators.
作者信息
Goldberg E D, Eshchenko V A, Bovt V D
机构信息
Tomsk Scientific Center, U.S.S.R. Academy of Medical Sciences.
出版信息
Exp Pathol. 1991;42(1):59-64. doi: 10.1016/s0232-1513(11)80038-1.
PMID:1879512
Abstract
Diabetogenic and acidotropic effects of dithizone, 8-(p-toluenesulfonylamino)-quinoline and 8-(benzenesulfonylamino)-quinoline were studied in experiments on cats, rabbits, golden hamsters and mice. Selective damage of insulin producing cells, phase glycemic fluctuations and permanent diabetes development were shown to be connected with chelator zinc binding in the lysosome-segregation apparatus of these cells.
摘要
在猫、兔、金黄仓鼠和小鼠身上进行的实验研究了双硫腙、8-（对甲苯磺酰氨基）喹啉和8-（苯磺酰氨基）喹啉的致糖尿病和嗜酸作用。胰岛素生成细胞的选择性损伤、血糖波动阶段和永久性糖尿病的发展被证明与这些细胞的溶酶体分离装置中螯合剂锌的结合有关。
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