Goldberg E D, Eshchenko V A, Bovt V D
Institute of Pharmacology, Tomsk Scientific Centre of U.S.S.R. Academy of Medical Sciences.
Endocrinologie. 1990 Apr-Jun;28(2):51-5.
The investigation of diabetogenic activity of chelators (dithizone and quinoline derivatives, was carried out in 6 mammalian species (dogs, cats, rabbits, rats, golden hamsters and mice). Rabbits are the most suitable animals for the production of diabetes with persistent hyperglycemia (permanent diabetes). The optimal conditions of such modelling are created by chelator injection of small doses to fasting rabbits. Diabetes resulting in recovery is well modelled in hamsters and mice. Chelators induce in Langerhans' islets of dogs, cats and rats alterations insufficient for diabetes development. These changes are easily revealed with zinc cytochemical reaction.
对螯合剂（双硫腙和喹啉衍生物）的致糖尿病活性进行了研究，实验对象为6种哺乳动物（狗、猫、兔、大鼠、金黄仓鼠和小鼠）。兔子是产生持续性高血糖（永久性糖尿病）的糖尿病最适宜的动物。通过向禁食的兔子注射小剂量螯合剂可创造出这种建模的最佳条件。仓鼠和小鼠能很好地模拟出可恢复的糖尿病。螯合剂在狗、猫和大鼠的胰岛中引起的改变不足以引发糖尿病。这些变化通过锌细胞化学反应很容易被发现。
