Komissarenko V P, Mikosha A S, Polovko E P
Probl Endokrinol (Mosk). 1978 Mar-Apr;24(2):85-9.
The action of the inhibitor of the adrenal gland function of dogs--o,n'-DDD--on ATP-ases was studied experimentally. In a concentration of 0.2--1.0 mM o,n'-DDD inhibited the Na+, K+. Mg2+-ATP-ases of the homogenate, and also the mitochondrial and microsomal fractions of the dog adrenal cortex. The effect of the inhibitor became intensified with the temperature elevation. An inhibition of ATP-ases in the homogenate and the microsomal fraction was noted as a result of a single feeding of o,n'-DDD to dogs (50 mg per 1 kg of body weight). A double o,n'-DDD feeding caused activation of the enzymes in the homogenate and the mitochondrial fraction.
对狗肾上腺功能抑制剂——邻对滴滴滴（o,n'-DDD）对ATP酶的作用进行了实验研究。在浓度为0.2 - 1.0 mM时，邻对滴滴滴抑制了匀浆以及狗肾上腺皮质线粒体和微粒体部分的Na⁺、K⁺、Mg²⁺ - ATP酶。随着温度升高，抑制剂的作用增强。给狗单次喂食邻对滴滴滴（每1千克体重50毫克）后，发现匀浆和微粒体部分的ATP酶受到抑制。而两次喂食邻对滴滴滴则导致匀浆和线粒体部分的酶被激活。
