通过绒毛取样和核型分析对95例孕早期自然流产病例进行研究。
Analyses of 95 first-trimester spontaneous abortions by chorionic villus sampling and karyotype.
作者信息
Strom C M, Ginsberg N, Applebaum M, Bozorgi N, White M, Caffarelli M, Verlinsky Y
机构信息
Reproductive Genetics Institute, Illinois Masonic Medical Center, Chicago 60657.
出版信息
J Assist Reprod Genet. 1992 Oct;9(5):458-61. doi: 10.1007/BF01204052.
PURPOSE
Our purpose was to determine the incidence of chromosomal aneuploidy in first-trimester pregnancy losses using chorionic villus sampling (CVS).
STUDY DESIGN
All patients presenting for CVS with no fetal cardiac activity were offered CVS.
RESULTS
Cytogenetic results were completed in 95 of 96 cases (99%). Eighty-three percent of the karyotypes were aneuploid. The 16 euploid fetuses had no excess of females.
CONCLUSION
CVS is the most reliable method of determining the karyotype of spontaneously aborted fetuses. The incidence of aneuploidy is much greater than in previous reports that analyzed passed products of conception. CVS should be offered to women who present with first-trimester spontaneous abortions.
目的
我们的目的是通过绒毛取样（CVS）来确定孕早期妊娠丢失时染色体非整倍体的发生率。
研究设计
所有前来进行CVS且无胎儿心脏活动的患者均接受了CVS。
结果
96例中的95例（99%）完成了细胞遗传学结果分析。83%的核型为非整倍体。16例整倍体胎儿中女性并无过多。
结论
CVS是确定自然流产胎儿核型最可靠的方法。非整倍体的发生率远高于以往分析妊娠产物的报告。对于出现孕早期自然流产的女性应提供CVS检查。
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