Gupta M M, Roth P, Werner E
Institute of Nuclear Medicine and Allied Sciences, Delhi, India.
Clin Phys Physiol Meas. 1992 Nov;13(4):411-8. doi: 10.1088/0143-0815/13/4/008.
A method is described for the quantitative analysis of in vivo organ measurements of 59Fe activity in ferrokinetic investigations. The time-activity curves obtained by sequential surface monitoring over sacrum, liver and spleen can be resolved quantitatively into their different components contributing to the recorded count rate. The analysis is performed in three steps: (1) Count rate contributions from activity in other organs and from scattered radiation from regions outside the organ under investigation are corrected. (2) Distinction is made between radioactivity uptake of the tissue and radioactivity contained in the perfusing blood. (3) The resulting net organ activity is then further resolved into an erythropoietic and a storage iron component by use of a computer program (SAAM-27) and assuming a compartmental model for internal iron exchange. The method was tested in three groups of patients with different haematological disorders and in normal controls. Characteristic patterns of the parameters are found for different diseases and the results correlated well with the clinical findings. It is concluded that in vivo organ measurements of 59Fe activity, when performed and analysed with sufficient care, can provide an insight into the dynamics of the iron exchange that is taking place in an organ. This analytical approach may improve the diagnostic predictions of ferrokinetic investigations.
本文描述了一种在铁动力学研究中对体内器官59Fe活性测量进行定量分析的方法。通过对骶骨、肝脏和脾脏进行连续表面监测获得的时间-活性曲线，可以定量解析为对记录计数率有贡献的不同成分。分析分三步进行：（1）校正来自其他器官活性以及来自被研究器官外部区域散射辐射的计数率贡献。（2）区分组织摄取的放射性和灌注血液中所含的放射性。（3）然后通过使用计算机程序（SAAM-27）并假设内部铁交换的隔室模型，将所得的净器官活性进一步解析为造血铁成分和储存铁成分。该方法在三组患有不同血液系统疾病的患者以及正常对照中进行了测试。发现了不同疾病的特征性参数模式，结果与临床发现相关性良好。结论是，当充分谨慎地进行和分析时，体内器官59Fe活性测量可以深入了解器官中发生的铁交换动态。这种分析方法可能会改善铁动力学研究的诊断预测。
