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1
Telomere elongation frequently observed during tumor metastasis.端粒延长在肿瘤转移过程中经常被观察到。
Jpn J Cancer Res. 1992 Nov;83(11):1124-7. doi: 10.1111/j.1349-7006.1992.tb02733.x.
2
Telomere change and loss of heterozygosity of mouse primary tumors and cell lines.小鼠原发性肿瘤和细胞系的端粒变化及杂合性缺失
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3
Somatic mutation during metastasis of a mouse fibrosarcoma line detected by DNA fingerprint analysis.通过DNA指纹分析检测到的小鼠纤维肉瘤细胞系转移过程中的体细胞突变。
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4
Telomerase activity and metastasis: expansion of cells having higher telomerase activity within culture lines and tumor tissues.端粒酶活性与转移：培养细胞系和肿瘤组织内具有较高端粒酶活性的细胞的扩增。
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Telomeric structure in cells with chromosome end associations.
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Extensive telomere repeat arrays in mouse are hypervariable.小鼠中广泛的端粒重复序列阵列具有高度变异性。
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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.人类端粒包含两种不同的与Myb相关的蛋白质，即端粒重复结合因子1（TRF1）和端粒重复结合因子2（TRF2）。
Nat Genet. 1997 Oct;17(2):231-5. doi: 10.1038/ng1097-231.
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Visualizing telomere dynamics in living mammalian cells using PNA probes.使用肽核酸（PNA）探针可视化活的哺乳动物细胞中的端粒动态变化。
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引用本文的文献

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Metastases suppressor NME2 associates with telomere ends and telomerase and reduces telomerase activity within cells.转移抑制因子 NME2 与端粒末端和端粒酶结合，并降低细胞内端粒酶的活性。
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Telomere change and loss of heterozygosity of mouse primary tumors and cell lines.小鼠原发性肿瘤和细胞系的端粒变化及杂合性缺失
Jpn J Cancer Res. 1993 Dec;84(12):1292-9. doi: 10.1111/j.1349-7006.1993.tb02837.x.

本文引用的文献

1
The Fusion of Broken Ends of Chromosomes Following Nuclear Fusion.核融合后染色体断端的融合
Proc Natl Acad Sci U S A. 1942 Nov;28(11):458-63. doi: 10.1073/pnas.28.11.458.
2
Biological diversity in metastatic neoplasms: origins and implications.转移性肿瘤中的生物多样性：起源与影响
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Establishment and immunologic characterization of 3-methylcholanthrene-induced sarcoma cell lines metastasizing widely in mice and exhibiting distinct and selective propensities for the mode of metastasis.3-甲基胆蒽诱导的肉瘤细胞系的建立及其免疫特性，该细胞系在小鼠体内广泛转移，并对转移方式表现出独特的选择性倾向。
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Growth of chromosome ends in multiplying trypanosomes.增殖型锥虫染色体末端的生长
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Mechanisms of tumor progression.肿瘤进展机制。
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Telomeric fusion in pre-T-cell acute lymphoblastic leukemia.前体T细胞急性淋巴细胞白血病中的端粒融合
Hum Genet. 1986 Jul;73(3):260-3. doi: 10.1007/BF00401240.
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Sequence organization and cytological localization of the minor satellite of mouse.小鼠微小卫星的序列组织和细胞学定位
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8
Genetic tagging of tumor cells with retrovirus vectors: clonal analysis of tumor growth and metastasis in vivo.用逆转录病毒载体对肿瘤细胞进行基因标记：体内肿瘤生长和转移的克隆分析
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9
Identification of healed terminal DNA fragments in linear minichromosomes of Schizosaccharomyces pombe.粟酒裂殖酵母线性小染色体中愈合末端DNA片段的鉴定。
Mol Cell Biol. 1987 Dec;7(12):4424-30. doi: 10.1128/mcb.7.12.4424-4430.1987.
10
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats.人类端粒末端转移酶是一种合成TTAGGG重复序列的核糖核蛋白。
Cell. 1989 Nov 3;59(3):521-9. doi: 10.1016/0092-8674(89)90035-4.

端粒延长在肿瘤转移过程中经常被观察到。

Telomere elongation frequently observed during tumor metastasis.

作者信息

Takada T, Hayashi T, Arakawa M, Kominami R

机构信息

First Department of Biochemistry, Niigata University School of Medicine.

出版信息

Jpn J Cancer Res. 1992 Nov;83(11):1124-7. doi: 10.1111/j.1349-7006.1992.tb02733.x.

DOI:10.1111/j.1349-7006.1992.tb02733.x
PMID:1483926
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5918703/
Abstract

Changes in the number of telomere repeat arrays have been examined during metastasis of two mouse tumor cell lines. Telomeres were detected as bands and a smear by pulsed-field gel electrophoresis and gel-hybridization using (TTAGGG)4 as a probe. Very long size variants of telomeres were frequently observed in metastatic nodules. This suggests that at least some of the tumor cells have an ability to elongate telomeres. This elongation may compensate for the continuous loss of telomere repeats due to cell divisions, which would eventually lead to cell death.

摘要

在两种小鼠肿瘤细胞系转移过程中，对端粒重复序列阵列的数量变化进行了研究。通过脉冲场凝胶电泳和使用(TTAGGG)4作为探针的凝胶杂交，将端粒检测为条带和涂片。在转移瘤结节中经常观察到端粒的非常长的大小变异体。这表明至少一些肿瘤细胞具有延长端粒的能力。这种延长可能补偿由于细胞分裂导致的端粒重复序列的持续丢失，而这最终会导致细胞死亡。