Smokovitis A, Astrup T
J Invest Dermatol. 1978 Jun;70(6):321-5. doi: 10.1111/1523-1747.ep12543490.
The distribution and intensity of fibrinolytic activity and of inhibitors of fibrinolysis in the normal skin of the rat, guinea pig and rabbit were studied with histochemical techniques. Rat skin exhibited the highest overall fibrinolytic activity and rabbit skin the lowest, with guinea-pig intermediate. The distribution of fibrinolytic areas differed in the different species. The fibrinolytic activity was caused by an activator of plasminogen related to the blood vessels or in some instances (mainly in the rabbit) to the epidermis. The ability to inhibit plasmin was highest in guinea pig skin and lowest in rat skin, with rabbit skin intermediate. In all 3 species the inhibition was related chiefly to the muscular layer. Epidermis was an additional source of inhibition.
采用组织化学技术研究了大鼠、豚鼠和家兔正常皮肤中纤溶活性及其抑制剂的分布和强度。大鼠皮肤的总体纤溶活性最高，家兔皮肤最低，豚鼠皮肤居中。不同物种的纤溶区域分布有所不同。纤溶活性是由与血管相关的纤溶酶原激活剂引起的，在某些情况下（主要在家兔中）是由表皮引起的。豚鼠皮肤抑制纤溶酶的能力最高，大鼠皮肤最低，家兔皮肤居中。在所有这3个物种中，抑制作用主要与肌肉层有关。表皮也是抑制作用的一个额外来源。
