可溶性T细胞因子对人混合淋巴细胞反应的抑制作用。该因子对反应细胞和刺激细胞的特异性。
Suppression of the mixed lymphocyte reaction in man by a soluble T-cell factor. Specificity of the factor for both responder and stimulator.
作者信息
Engleman E G, McMichael A J, McDevitt H O
出版信息
J Exp Med. 1978 Apr 1;147(4):1037-43. doi: 10.1084/jem.147.4.1037.
Abstract
J.H., an HLA-Dw2 homozygous multiparous woman, fails to respond to her husband, W.H. (HLA Dw1,-) in the unidirectional mixed lymphocyte reaction. T cells from J.H. were previously shown to suppress the responses of Dw2-positive cells but not Dw2-negative cells to W.H. We now report that a soluble factor released into the supernate of the mixed lymphocyte reaction by J.H. T cells, mediates this suppression. Like the cell from which it is derived, the factor is highly specific for HLA Dw2 in the responder cell and partially specific for the stimulatory alloantigen.
摘要
J.H.是一位HLA - Dw2纯合的经产妇，在单向混合淋巴细胞反应中对其丈夫W.H.（HLA Dw1，-）无反应。先前已表明，J.H.的T细胞可抑制Dw2阳性细胞而非Dw2阴性细胞对W.H.的反应。我们现在报告，J.H.的T细胞在混合淋巴细胞反应的上清液中释放的一种可溶性因子介导了这种抑制作用。与产生它的细胞一样，该因子对反应细胞中的HLA Dw2具有高度特异性，对刺激同种异体抗原具有部分特异性。
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