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人混合淋巴细胞反应中对刺激同种异体抗原具有特异性的抑制性T细胞。有证据表明，抑制作用需要抑制细胞和反应细胞在HLA-D位点上具有相同的抗原。

A suppressor T cell of the mixed lymphocyte reaction in man specific for the stimulating alloantigen. Evidence that identity at HLA-D between suppressor and responder is required for suppression.

作者信息

Engleman E G, McMichael A J, Batey M E, McDevitt H O

出版信息

J Exp Med. 1978 Jan 1;147(1):137-46. doi: 10.1084/jem.147.1.137.

DOI:10.1084/jem.147.1.137
PMID:75232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2184102/
Abstract

It has previously been shown that J.H., a human leukocyte antigen (HLA)-Dw2 homozygous multiparous woman, fails to respond in a mixed lymphocyte reaction (MLR) to her Dw1 homozygous husband W.H., and that her T cells suppress the responses of HLA matched responders to W.H. The present studies take advantage of the observation that J.H. suppressor cells resist a dose of gamma-irradiation which functionally eliminates her MLR responder cells. J.H. cells, depleted of alloreactive cells, suppress the responses of Dw2 heterozygous or homozygous cells to W.H., regardless of their associated HLA-A or B antigens. Only when W.H. or a few other cells are present as the irradiated stimulator is J.H. suppression of Dw2 responses detected. Thus, the J.H. suppressor T cell recognizes determinants in the irradiated stimulator cells as well as D locus products in the responder.

摘要

先前的研究表明，J.H.是一位人类白细胞抗原（HLA）-Dw2纯合多产女性，在混合淋巴细胞反应（MLR）中对其Dw1纯合丈夫W.H.无反应，并且她的T细胞抑制了HLA匹配的应答者对W.H.的反应。目前的研究利用了这样一个观察结果，即J.H.的抑制细胞能抵抗一定剂量的γ射线照射，而该剂量在功能上消除了她的MLR应答细胞。去除了同种反应性细胞的J.H.细胞，无论其相关的HLA-A或B抗原如何，均能抑制Dw2杂合或纯合细胞对W.H.的反应。只有当W.H.或其他少数细胞作为经照射的刺激细胞存在时，才能检测到J.H.对Dw2反应的抑制作用。因此，J.H.抑制性T细胞识别经照射的刺激细胞中的决定簇以及应答者中的D位点产物。

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Three closely linked genetic systems relevant to transplantation.与移植相关的三个紧密相连的遗传系统。
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Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.小鼠抗体应答调节中抗原特异性抑制性T细胞因子的特性。IV. H-2组织相容性复合体内编码抑制性T细胞因子的基因的特殊亚区定位
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