人类混合淋巴细胞反应中的抑制性T细胞。
A suppressor T cell in the human mixed lymphocyte reaction.
作者信息
McMichael A J, Sasazuki T
出版信息
J Exp Med. 1977 Aug 1;146(2):368-80. doi: 10.1084/jem.146.2.368.
Abstract
Lymphocytes from an HLA-B7 DW2 homozygous multiparous woman, J.H., failed to respond in the mixed lymphocyte reaction to lymphocytes from her DW1 homozygous husband, W.H., and certain other homozygous typing cells. J.H. lymphocytes could suppress the response of HLA matched responders to W.H. This effect was shown to be radiosensitive and due to a T cell. The suppressor cell showed antigen specificity.
摘要
来自一位 HLA - B7 DW2 纯合多产女性 J.H. 的淋巴细胞，在混合淋巴细胞反应中对她的 DW1 纯合丈夫 W.H. 的淋巴细胞以及某些其他纯合分型细胞无反应。J.H. 的淋巴细胞可抑制 HLA 匹配的反应者对 W.H. 的反应。这种效应显示对辐射敏感且归因于 T 细胞。抑制细胞表现出抗原特异性。
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