青少年慢性关节炎亚组中抗组蛋白抗体的鉴定。
Identification of antihistone antibodies in subsets of juvenile chronic arthritis.
作者信息
Ostensen M, Fredriksen K, Kåss E, Rekvig O P
机构信息
Oslo Sanitetsforening Rheumatism Hospital, Norway.
出版信息
Ann Rheum Dis. 1989 Feb;48(2):114-7. doi: 10.1136/ard.48.2.114.
Antihistone antibodies (AHAs) as measured by an enzyme linked immunosorbent assay (ELISA) were detected in the sera of 58 (48%) of 121 unselected patients with juvenile chronic arthritis (JCA). AHAs were found in 28 (93%) of 30 patients with JCA with uveitis but in only 30 (33%) of 91 patients with JCA without uveitis. AHA positivity was unrelated to the type of joint involvement, disease activity, and drug regimen. When the AHA positive group was divided into 28 patients with JCA with uveitis and 30 patients with JCA without uveitis a distinct response pattern of AHA was detected in each group. Anti-H3 dominated in the JCA/uveitis group, whereas a more heterogeneous AHA pattern was shown in the group without uveitis. The results indicate that subtyping for AHA reactivity may define patients who are highly susceptible for the development of anterior uveitis.
通过酶联免疫吸附测定（ELISA）检测发现，121例未经挑选的青少年慢性关节炎（JCA）患者中，58例（48%）血清中存在抗组蛋白抗体（AHA）。30例患有葡萄膜炎的JCA患者中，28例（93%）存在AHA；而91例无葡萄膜炎的JCA患者中，仅30例（33%）存在AHA。AHA阳性与关节受累类型、疾病活动度及药物治疗方案无关。当将AHA阳性组分为28例患有葡萄膜炎的JCA患者和30例无葡萄膜炎的JCA患者时，在每组中均检测到AHA的不同反应模式。在JCA/葡萄膜炎组中，抗H3占主导，而在无葡萄膜炎组中，AHA模式更为多样。结果表明，AHA反应性亚型分类可能有助于确定极易发生前葡萄膜炎的患者。
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