Leak A M, Tuaillon N, Muller S, Woo P
Royal Sea Bathing Hospital, Margate, Kent.
Br J Rheumatol. 1993 May;32(5):426-31. doi: 10.1093/rheumatology/32.5.426.
The objective of this study was to determine the prevalence of histone antibodies in early onset pauciarticular juvenile chronic arthritis (JCA), and to assess any association with disease activity in terms of arthritis or uveitis. Forty-four children with early onset pauciarticular JCA have been assessed prospectively using clinical and laboratory parameters. Sera were collected from these patients during clinical follow-up. Some of them had serial measurements during the period of study. Patient sera were analysed for histone antibodies by ELISA. A further study using 30 synthetic peptides of calf thymus core histones was performed by ELISA. Seventy-five per cent of children have IgM antibodies to histone, usually to more than one type. The highest values were anti H3 and H4 antibodies. There was no correlation between the level of anti-histone antibodies and anterior uveitis. There were increased levels of IgG antibodies to histone peptides, in particular the N- and C-terminal peptides of H3 in 70.5% of children. Antibodies to H3 peptides tend to be in patients with chronic anterior uveitis (P = 0.04).
本研究的目的是确定早发型少关节型幼年慢性关节炎（JCA）中组蛋白抗体的患病率，并根据关节炎或葡萄膜炎评估其与疾病活动的任何关联。已使用临床和实验室参数对44例早发型少关节型JCA患儿进行了前瞻性评估。在临床随访期间从这些患者中采集血清。他们中的一些人在研究期间进行了系列测量。通过ELISA分析患者血清中的组蛋白抗体。通过ELISA对30种小牛胸腺核心组蛋白的合成肽进行了进一步研究。75%的儿童有针对组蛋白的IgM抗体，通常针对不止一种类型。最高值是抗H3和H4抗体。抗组蛋白抗体水平与前葡萄膜炎之间没有相关性。70.5%的儿童中针对组蛋白肽的IgG抗体水平升高，特别是H3的N端和C端肽。针对H3肽的抗体往往出现在慢性前葡萄膜炎患者中（P = 0.04）。
