Leak A M, Ansell B M, Burman S J
Arch Dis Child. 1986 Feb;61(2):168-72. doi: 10.1136/adc.61.2.168.
This study of children with chronic arthritis confirms that patients at greatest risk for chronic iridocyclitis have a young age of onset and positive antinuclear antibodies (ANA). Children who are ANA negative have a low risk of iridocyclitis. When it occurs it is at a significantly older age. No child developing juvenile chronic arthritis over 9, even with positive ANA, had chronic iritis. There was remarkable variation in ANA titres; these correlated with erythrocyte sedimentation rate, active arthritis, and iridocyclitis. Maximum ANA titres were often seen very early in the disease but at this time were usually not associated with a poor prognosis. Histocompatibility antigens A2 and DRw8 were significantly increased, suggesting primary associations in pauciarticular arthritis with ANA. HLA-DR5 was associated with mild forms of arthritis and with absence of, or only mild, iritis. HLA-B15/w62 was associated with severe forms of eye involvement.
这项针对慢性关节炎患儿的研究证实，慢性虹膜睫状体炎风险最高的患者发病年龄小且抗核抗体（ANA）呈阳性。ANA阴性的儿童患虹膜睫状体炎的风险较低。若发病，其发病年龄显著偏大。9岁以上患青少年慢性关节炎的儿童，即便ANA呈阳性，也不会患慢性虹膜炎。ANA滴度存在显著差异；这些差异与红细胞沉降率、活动性关节炎及虹膜睫状体炎相关。ANA滴度最高值常在疾病早期出现，但此时通常与预后不良无关。组织相容性抗原A2和DRw8显著增加，提示在少关节型关节炎中与ANA存在原发性关联。HLA - DR5与轻度关节炎形式以及无虹膜睫状体炎或仅有轻度虹膜睫状体炎相关。HLA - B15/w62与严重的眼部受累形式相关。
