Mancia G, Giannattasio C, Omboni S
Cattedra di Medicina Interna, Ospedale S. Gerardo Monza, Università di Milano, Italy.
Eur Heart J. 1992 Dec;13 Suppl G:43-7. doi: 10.1093/eurheartj/13.suppl_g.43.
This paper outlines the advantages of ambulatory blood pressure monitoring (ABPM) in the evaluation of the efficacy of antihypertensive drugs. The main advantage is that ABPM allows the antihypertensive effect of a drug or drug regimen to be determined in daily life conditions and to uncover whether the treatment employed is associated with untoward hypotensive episodes. Furthermore, ABPM facilitates the design of studies on antihypertensive drug efficacy because the 24 h mean blood pressure is devoid of a placebo effect and its reproducibility is much greater than office blood pressure. This has permitted demonstration of the efficacy of several antihypertensive drug regimens, including diuretic studies, based on relatively small numbers of subjects. A further advantage of ABPM is that it allows drug treatment efficacy to be evaluated in relation to blood pressure variability, another possible determinant of the organ damage related to hypertension.
本文概述了动态血压监测（ABPM）在评估抗高血压药物疗效方面的优势。主要优势在于，ABPM能够在日常生活条件下确定一种药物或药物治疗方案的降压效果，并发现所采用的治疗是否与不良低血压发作相关。此外，ABPM有助于抗高血压药物疗效研究的设计，因为24小时平均血压不存在安慰剂效应，且其可重复性远高于诊室血压。这使得基于相对少量受试者就能证明几种抗高血压药物治疗方案的疗效，包括利尿剂研究。ABPM的另一个优势是，它能够根据血压变异性来评估药物治疗效果，而血压变异性是与高血压相关的器官损害的另一个可能决定因素。
