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一锅法微波辅助合成吡啶并[2,3-d]嘧啶。

A one-pot microwave-assisted synthesis of pyrido[2,3-d]pyrimidines.

作者信息

Mont Núria, Teixidó Jordi, Kappe C Oliver, Borrell José I

机构信息

Grup d'Enginyeria Molecular, Institut Químic de Sarrià, Universitat Ramon Llull, Barcelona, Spain.

出版信息

Mol Divers. 2003;7(2-4):153-9. doi: 10.1023/b:modi.0000006808.10647.f8.

DOI:10.1023/b:modi.0000006808.10647.f8
PMID:14870844
Abstract

A high yield multicomponent reaction providing multifunctionalized pyrido[2,3-d]pyrimidines with up to four diversity centers in a one-pot microwave-assisted cyclocondensation of alpha,beta-unsaturated esters, amidine systems and malononitrile (or ethyl cyanoacetate) is described.

摘要

描述了一种高产率的多组分反应，该反应通过α,β-不饱和酯、脒体系和丙二腈（或氰基乙酸乙酯）的一锅法微波辅助环缩合反应，提供具有多达四个多样性中心的多功能化吡啶并[2,3-d]嘧啶。

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Recent advances in isocyanide-based multicomponent chemistry.基于异腈的多组分化学的最新进展。
Curr Opin Chem Biol. 2002 Jun;6(3):306-13. doi: 10.1016/s1367-5931(02)00328-9.
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Multi-component reactions and evolutionary chemistry.
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