Lamers C T J, Ramaekers J G, Muntjewerff N D, Sikkema K L, Samyn N, Read N L, Brookhuis K A, Riedel W J
Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Maastricht University, Maastricht, The Netherlands.
J Psychopharmacol. 2003 Dec;17(4):379-87. doi: 10.1177/0269881103174015.
Ecstasy (3,4-methylenedioxymethamphetamine, MDMA) is a psychoactive recreational drug widely used by young people visiting dance parties, and has been associated with poor cognitive function. The current study assessed the influence of a single dose of MDMA 75 mg and alcohol 0.5 g/kg on cognition, psychomotor performance and driving-related task performance. Twelve healthy recreational ecstasy users participated in an experimental study conducted according to a double-blind, double-dummy, placebo-controlled three-way cross-over design. MDMA improved psychomotor performance, such as movement speed and tracking performance in a single task, as well as in a divided attention task. MDMA impaired the ability to predict object movement under divided attention. However, the inability to accurately predict object movement after MDMA may indicate impairment of particular performance skills relevant to driving. There was no effect of MDMA on visual search, planning or retrieval from semantic memory.
摇头丸（3,4-亚甲基二氧甲基苯丙胺，MDMA）是一种精神活性娱乐性药物，在参加舞会的年轻人中广泛使用，且与认知功能不佳有关。本研究评估了单次服用75毫克MDMA和0.5克/千克酒精对认知、精神运动表现及驾驶相关任务表现的影响。12名健康的摇头丸娱乐使用者参与了一项按照双盲、双模拟、安慰剂对照三向交叉设计进行的实验研究。MDMA改善了精神运动表现，如在单一任务以及分心任务中的运动速度和跟踪表现。MDMA损害了在分心状态下预测物体运动的能力。然而，服用MDMA后无法准确预测物体运动可能表明与驾驶相关的特定表现技能受损。MDMA对视觉搜索、规划或语义记忆检索没有影响。
