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High-level aminoglycoside-resistant enterococci. Colonization of nursing home and acute care hospital patients.
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In vitro activity of ciprofloxacin against gram-positive bacteria. An overview.
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Enterococcal superinfection in patients treated with ciprofloxacin.接受环丙沙星治疗的患者发生肠球菌二重感染。
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Identification of Streptococcus faecalis and Streptococcus faecium and susceptibility studies with newly developed antimicrobial agents.粪肠球菌和屎肠球菌的鉴定以及新型抗菌剂的药敏研究。
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Nosocomial infection by gentamicin-resistant Streptococcus faecalis. An epidemiologic study.耐庆大霉素粪肠球菌的医院感染。一项流行病学研究。
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High-level penicillin resistance among isolates of enterococci. Implications for treatment of enterococcal infections.肠球菌分离株中的高水平青霉素耐药性。对肠球菌感染治疗的影响。
Ann Intern Med. 1989 Apr 1;110(7):515-20. doi: 10.7326/0003-4819-110-7-515.
9
Enterococci highly resistant to penicillin and ampicillin: an emerging clinical problem?对青霉素和氨苄西林高度耐药的肠球菌：一个新出现的临床问题？
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10
In vitro activities of quinolones against enterococci resistant to penicillin-aminoglycoside synergy.喹诺酮类药物对耐青霉素-氨基糖苷类协同作用肠球菌的体外活性。
Antimicrob Agents Chemother. 1989 Jan;33(1):71-7. doi: 10.1128/AAC.33.1.71.

肠球菌对环丙沙星的耐药性增强。

Increasing resistance of enterococci to ciprofloxacin.

作者信息

Schaberg D R, Dillon W I, Terpenning M S, Robinson K A, Bradley S F, Kauffman C A

机构信息

Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor 48109.

出版信息

Antimicrob Agents Chemother. 1992 Nov;36(11):2533-5. doi: 10.1128/AAC.36.11.2533.

DOI:10.1128/AAC.36.11.2533
PMID:1489199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC284368/
Abstract

We determined that resistance to ciprofloxacin has emerged in enterococci over the last 5 years in our hospital, mainly in strains demonstrating the phenotype of high-level gentamicin resistance. All high-level-gentamicin-resistant isolates from 1985 and 1986 were susceptible, whereas 24% of isolates from 1989 and 1990 were resistant to ciprofloxacin. Plasmid and genomic DNA typing showed at least six unique strains exhibiting resistance, but one type accounted for 80% of recent resistant isolates, suggesting a role for cross infection in the emergence of resistance.

摘要

我们确定，过去5年里我院肠球菌中出现了对环丙沙星的耐药性，主要出现在表现出高水平庆大霉素耐药表型的菌株中。1985年和1986年所有高水平庆大霉素耐药菌株均敏感，而1989年和1990年的分离株中有24%对环丙沙星耐药。质粒和基因组DNA分型显示至少有6种独特的耐药菌株，但其中一种类型占近期耐药分离株的80%，提示交叉感染在耐药性出现中起作用。