Schaberg D R, Dillon W I, Terpenning M S, Robinson K A, Bradley S F, Kauffman C A
Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor 48109.
Antimicrob Agents Chemother. 1992 Nov;36(11):2533-5. doi: 10.1128/AAC.36.11.2533.
We determined that resistance to ciprofloxacin has emerged in enterococci over the last 5 years in our hospital, mainly in strains demonstrating the phenotype of high-level gentamicin resistance. All high-level-gentamicin-resistant isolates from 1985 and 1986 were susceptible, whereas 24% of isolates from 1989 and 1990 were resistant to ciprofloxacin. Plasmid and genomic DNA typing showed at least six unique strains exhibiting resistance, but one type accounted for 80% of recent resistant isolates, suggesting a role for cross infection in the emergence of resistance.
我们确定,过去5年里我院肠球菌中出现了对环丙沙星的耐药性,主要出现在表现出高水平庆大霉素耐药表型的菌株中。1985年和1986年所有高水平庆大霉素耐药菌株均敏感,而1989年和1990年的分离株中有24%对环丙沙星耐药。质粒和基因组DNA分型显示至少有6种独特的耐药菌株,但其中一种类型占近期耐药分离株的80%,提示交叉感染在耐药性出现中起作用。