Dueńas-Barajas E, Bernal J E, Vaught D R, Briceño I, Durán C, Yanagihara R, Gajdusek D C
Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
AIDS Res Hum Retroviruses. 1992 Nov;8(11):1851-5. doi: 10.1089/aid.1992.8.1851.
High prevalences of human T-lymphotropic virus type II (HTLV-II) infection have been found recently among certain Amerindian groups in North, Central, and South America. To determine if the Amerindians of Colombia are similarly affected, 523 sera, collected between 1987 and 1990 from nine culturally distinct Indian groups from widely separated regions, were tested for IgG antibodies against HTLV-I/II using enzyme-linked immunosorbent assay (ELISA) and Western blot. In addition, 243 sera from five non-Indian (black) and mixed-Indian (mestizo) populations were studied. Of the 766 individuals tested, 44 were ELISA positive, but of these, only four were Western blot positive. Three of the individuals confirmed positive by Western blot were infected with HTLV-II and one was infected with HTLV-I, as determined by differential ELISA. All four seropositive individuals belonged to a group of 62 Wayuu Indians, giving overall HTLV-I and HTLV-II seroprevalences of 1.6% and 4.8%, respectively. The coexistence of HTLV-I and HTLV-II in this Amerindian group provides an opportunity to study the factors governing transmission of these retroviruses.
最近在北美洲、中美洲和南美洲的某些美洲印第安人群体中发现了较高的人类嗜T淋巴细胞病毒II型（HTLV-II）感染率。为了确定哥伦比亚的美洲印第安人是否也受到类似影响，使用酶联免疫吸附测定（ELISA）和蛋白质印迹法，对1987年至1990年间从广泛分布地区的9个文化不同的印第安群体收集的523份血清进行了HTLV-I/II IgG抗体检测。此外，还研究了来自5个非印第安（黑人）和印第安混血（梅斯蒂索人）人群的243份血清。在检测的766个人中，44人ELISA呈阳性，但其中只有4人蛋白质印迹呈阳性。通过差异ELISA确定，蛋白质印迹确认阳性的个体中有3人感染了HTLV-II，1人感染了HTLV-I。所有4名血清阳性个体都属于62名瓜尤印第安人群体，HTLV-I和HTLV-II的总体血清阳性率分别为1.6%和4.8%。该美洲印第安人群体中HTLV-I和HTLV-II的共存为研究控制这些逆转录病毒传播的因素提供了机会。
