AINSLIE J D
J Exp Med. 1952 Jan;95(1):9-18. doi: 10.1084/jem.95.1.9.
The early phase of growth of the Lansing strain of poliomyelitis virus in the mouse brain and cord was suppressed, or delayed, by the intraperitoneal administration of sodium monofluoroacetate in doses of 6 mg./kg. but not of 3 mg./kg. 1 hour before the intracerebral inoculation of virus. There was also a delay in the time at which the first signs of illness appeared in the treated mice. Similar effects, but to a lesser degree, were observed after the administration of DL-methionine sulfoximine in doses of 150 mg./kg. and 75 mg./kg. Sodium fluoroacetate in very high concentration had no direct effect in vitro on the infectivity of poliomyelitis virus. It was found that in each instance in which the growth of virus was delayed, the time at which the first obvious signs of illness appeared was also delayed in a proportionate manner. The significance of these findings is discussed, as well as the use of the growth curve of poliomyelitis virus in mice in studying the relation of cellular metabolism to viral synthesis and the search for effective chemical agents.
在脑内接种病毒前1小时，腹腔注射剂量为6毫克/千克而非3毫克/千克的一氟醋酸钠，可抑制或延迟兰辛株脊髓灰质炎病毒在小鼠脑和脊髓中的早期生长。接受治疗的小鼠出现疾病最初症状的时间也有所延迟。在给予剂量为150毫克/千克和75毫克/千克的DL-蛋氨酸亚砜胺后，观察到了类似但程度较轻的效果。高浓度的氟醋酸钠在体外对脊髓灰质炎病毒的感染性无直接影响。研究发现，在病毒生长延迟的每一个实例中，出现疾病最初明显症状的时间也相应延迟。本文讨论了这些发现的意义，以及利用小鼠体内脊髓灰质炎病毒的生长曲线来研究细胞代谢与病毒合成的关系和寻找有效化学药剂的情况。
