Sato H, Kamiya H, Hanada K
Department of Parasitology, Hirosaki University School of Medicine, Japan.
J Parasitol. 1992 Dec;78(6):1006-10.
Five confirmed human cases of gnathostomiasis nipponica exhibiting creeping eruption and itching were found sporadically from the autumn of 1991 to the winter of 1992 in the northern region of the mainland of Japan. In all cases, a causative gnathostome with 3 transverse rows of hooklets on the head bulb was detected in biopsied skin. The morphological characteristics agreed with the advanced third-stage larvae of Gnathostoma nipponicum. Within a few weeks before development of symptoms, all patients had histories of eating raw freshwater fishes, kokanee (Salmo nerka nerka), carp (Cyprinus carpio), crucian carp (Carassius gibelio langsdorfi), or common ice-fish (Salangichthys microdon). However, they had never eaten raw loach, which is known as a source of human infections with G. nipponicum.
1991年秋至1992年冬期间，在日本本土北部地区偶尔发现了5例确诊的日本颚口线虫病患者，均表现为匐行疹和瘙痒。所有病例在活检皮肤中均检测到头部球茎上有3排横向小钩的致病性颚口线虫。形态特征与日本颚口线虫的晚期第三期幼虫一致。在症状出现前几周内，所有患者均有食用生淡水鱼的历史，如红大麻哈鱼（Salmo nerka nerka）、鲤鱼（Cyprinus carpio）、鲫鱼（Carassius gibelio langsdorfi）或公鱼（Salangichthys microdon）。然而，他们从未食用过生泥鳅，泥鳅是已知的人类感染日本颚口线虫的来源。
