SMITH W E, KIDD J G, ROUS P
J Exp Med. 1952 Mar;95(3):299-318. doi: 10.1084/jem.95.3.299.
Three out of four carcinomas arising from rims-induced, rabbit papillomas have grown well after transplantation to sucklings. Two were propagated serially, and it seems likely that all could have been maintained indefinitely had litters been available of newborn animals of the sort in which they arose. These successes are the more worthy of note because of the well-nigh uniform failure of similar growths on transfer to adults. The tumors enlarged with great rapidity in the sucklings, were extraordinarily destructive, and two of them metastaslzed within a few weeks. Many efforts were made to extract causative agents from the three carcinomas, on the assumption that these might be due to variants of the Shope virus. Highly favorable conditions for the demonstration of this latter were provided in the tests; yet their outcome was wholly negative although all of the cancers derived from papillomas caused by "recoverable" strains of virus, and although one of them appeared to be consequent upon only the slightest of alterations toward malignancy on the part of the papilloma from which it came. Extracts of another of the cancers, an anaplastic, squamous-cell carcinoma devoid of any morphological sign of the influence of the Shope virus, yielded typical virus papillomas on several occasions. The wholly negative results with the third cancer must be considered in the light of the fact that the "recoverable" strain of virus causing the papilloma from which it originated could no longer be recovered from such growths on collateral test.
源自兔乳头瘤（由边缘诱导产生）的四分之三的癌，在移植到乳鼠后生长良好。其中两例进行了连续传代，而且如果有它们所源自的那种新生动物的幼崽，似乎所有这些癌都可以无限期维持下去。这些成功更值得注意，因为类似的肿瘤转移到成年动物身上几乎总是失败。这些肿瘤在乳鼠体内迅速增大，具有极强的破坏性，其中两例在几周内就发生了转移。人们多次尝试从这三种癌中提取致病因子，假定它们可能是肖普病毒的变种。试验中为证明后者提供了极为有利的条件；然而，尽管所有这些癌都源自由“可恢复”毒株病毒引起的乳头瘤，而且其中一例似乎仅仅是其来源的乳头瘤向恶性方向发生了最轻微的改变所致，但结果完全为阴性。另一种癌是未分化的鳞状细胞癌，没有任何肖普病毒影响的形态学迹象，其提取物多次产生典型的病毒乳头瘤。鉴于从导致其起源的乳头瘤中提取的“可恢复”毒株病毒在附带试验中已无法从这种生长物中再分离出来这一事实，必须考虑第三种癌的完全阴性结果。
